Notes on Stress


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There are problems of definition - what is your concept of stress?

  1. for humans...
  2. for animals...

  3.  

Essentially, stress occurs when an animal (human or otherwise) cannot react to remove a stressor (which could be real, potential, or perceived threat to well-being).
This intrusion and its perception as a threat results in behaviour, which serves to remove the stressor - i.e. to close the loop , negative feedback.
If, however, the situation is such that the stressor cannot be removed by behaviour (i.e. open-loop situation), then a physiological condition results which is termed STRESS.

An essential feature of this is departure from the body's normal homeostatic levels.
 

Possible measures of stress?

Associated changes in levels of certain hormones.

Increased risk of pathological conditions, e.g. cardiovascular problems, increase incidence of URTIs.

Abnormal behaviour, e.g. stereotypies.
 

Physiological changes

involve

Fright, fight or flight response:-


This may be adaptive as enabling animal to react effectively to a threatening situation; this is so in the short term - the General Adaptive Syndrome.

However, if the stressful situation persists, long-term stress resu1ts in several physiological conditions which are potentially harmful.
 

Autonomic nervous system: ANS divisions


has either a direct effect using noradrenalin as neurotransmiuer at neuromuscular junctions to affect heart rate etc.

or indirect, by its action on the adrenal medulla to release adrenalin and noradrenalin.

Adrenalin and noradrenalin are both catecholamines.
 
 
 
 
 
 
 
 
 
 

Hypothalamus -pituitary-adrenal cortex:HPA axis


HPA axis

CRH = corticotropin-releasing hormone - secreted by the hypothalamus

ACTH = adrenocorticotropic hormone - secreted by the pituitary - resulting in increased corticosteroid levels in the blood
 

The diagram below shows changes in hormonal levels with time after the onset of a stressor.

 
 
 

Stress and the Immune System

But - there can then be problems because of the effects of stress on the immune systemEffects of stress on immune system

- as shown in the next diagram.
 
 

Find out more about the immune system and immunity.
 
 

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